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研究称维生素D可缓解多发性硬化症症状
WASHINGTON, Jan. 20 (Xinhua) -- Patients in the early stages of multiple sclerosis (MS) could "stave off disease symptoms" by increasing their vitamin D intake1, U.S. researchers said Monday.
The study, published in the U.S. journal JAMA Neurology, found that levels of vitamin D were strongly associated with disease severity and speed of progression in early-stage MS patients.
"Because low vitamin D levels are common and can be easily and safely increased by oral supplementation, these findings may contribute to better outcomes for many MS patients," said lead author Alberto Ascherio, professor of epidemiology and nutrition at the Harvard School of Public Health.
Multiple sclerosis is a central nervous system disease that causes problems with muscle control and strength, vision, balance, feeling, and thinking. The World Health Organization estimated that roughly 2.5 million people in the world have the disease.
The researchers analyzed2 data from 465 MS patients from 18 European countries, as well as Israel and Canada who enrolled3 in 2002 and 2003 in a trial looking at the effectiveness of the drug interferon beta-1b in treating the disease.
Vitamin D levels were measured at the onset4 of their symptoms and at regular intervals5 over a 24-month period. The results were then correlated with their disease symptoms and progression over a period of five years.
They found that early-stage MS patients who had adequate levels of vitamin D had a 57 percent lower rate of new brain lesions, a 57 percent lower relapse rate, and a 25 percent lower yearly increase in lesion volume than those with lower levels of vitamin D.
Loss in brain volume, which is an important predictor of disability, was also lower among patients with adequate vitamin D levels.
The results suggest that vitamin D has a strong protective effect on the disease process underlying6 MS, and underscore the importance of correcting vitamin D insufficiency, which is widespread in Europe and the U.S., the researchers said.
"The benefits of vitamin D appeared to be additive7 to those of interferon beta-1b, a drug that is very effective in reducing MS activity," said Ascherio.
"The findings of our study indicate that identifying and correcting vitamin D insufficiency should become part of the standard of care for newly diagnosed MS patients."
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1 intake | |
n.吸入,纳入;进气口,入口 | |
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2 analyzed | |
v.分析( analyze的过去式和过去分词 );分解;解释;对…进行心理分析 | |
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3 enrolled | |
adj.入学登记了的v.[亦作enrol]( enroll的过去式和过去分词 );登记,招收,使入伍(或入会、入学等),参加,成为成员;记入名册;卷起,包起 | |
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4 onset | |
n.进攻,袭击,开始,突然开始 | |
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5 intervals | |
n.[军事]间隔( interval的名词复数 );间隔时间;[数学]区间;(戏剧、电影或音乐会的)幕间休息 | |
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6 underlying | |
adj.在下面的,含蓄的,潜在的 | |
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7 additive | |
adj.附加的;n.添加剂 | |
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