60秒科学:Cancer Drugs May Also Treat Alcoholism

As we recover from the holiday weekend, there’s some intoxicating¹ news on curbing² the effects of alcohol. In the May 29th issue of Cell, scientists report discovering a gene³ that controls fruit flies’ sensitivity to ethanol. And if that just sounds like tipsytalk, the finding suggests that a couple of current anticancer drugs might find use in treating alcoholism.

Some flies, like some people, just can’t hold their drink. One sip⁴ and they’re tripping over their own wings. So the scientists set out to search for the fly genes⁵ involved in alcohol sensitivity. And they turned up a gene they call happyhour. Flies with a normal version of this gene are liquor light-weights, while happyhour mutants can drink their fly friends under the table.

In the normal flies, happyhour blocks a hormone⁶ called EGF. And the scientists found that two anticancer drugs, which also inhibit⁷ EGF, make boozing flies more woozy—a feeling that’s as unpleasant for flies as it is for people. Rats, too, will take a nip and say enough when they’re on these drugs.

Robbing booze of its buzz is one way to attack alcoholism. Which means that, at least genetically⁸ speaking, it’s good to have a little happyhour.

—Karen Hopkin

1 intoxicating   

a. 醉人的,使人兴奋的

参考例句：

• Power can be intoxicating. 权力能让人得意忘形。
• On summer evenings the flowers gave forth an almost intoxicating scent. 夏日的傍晚，鲜花散发出醉人的芳香。

2 curbing   

n.边石，边石的材料v.限制，克制，抑制( curb的现在分词 )

参考例句：

• Progress has been made in curbing inflation. 在控制通货膨胀方面已取得了进展。
• A range of policies have been introduced aimed at curbing inflation. 为了抑制通货膨胀实施了一系列的政策。

3 gene   

n.遗传因子，基因

参考例句：

• A single gene may have many effects.单一基因可能具有很多种效应。
• The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。

4 sip   

v.小口地喝，抿，呷；n.一小口的量

参考例句：

• She took a sip of the cocktail.她啜饮一口鸡尾酒。
• Elizabeth took a sip of the hot coffee.伊丽莎白呷了一口热咖啡。

5 genes   

n.基因( gene的名词复数 )

参考例句：

• You have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因，所以能够活得很长。 来自《简明英汉词典》
• Differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪

6 hormone   

n.荷尔蒙，激素，内分泌

参考例句：

• Hormone implants are used as growth boosters.激素植入物被用作生长辅助剂。
• This hormone interacts closely with other hormones in the body.这种荷尔蒙与体內其他荷尔蒙紧密地相互作用。

7 inhibit   

vt.阻止，妨碍，抑制

参考例句：

• Don't let ego and greed inhibit clear thinking and hard work.不要让自我和贪婪妨碍清晰的思维和刻苦的工作。
• They passed a law to inhibit people from parking in the street.他们通过一项法令以阻止人们在街上停车。

8 genetically   

adv.遗传上

参考例句：

• All the bees in the colony are genetically related. 同一群体的蜜蜂都有亲缘关系。
• Genetically modified foods have already arrived on American dinner tables. 经基因改造加工过的食物已端上了美国人的餐桌。 来自英汉非文学 - 生命科学 - 基因与食物