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Feeling down? You’re not alone. If depression seems pretty common, it is. One in every ten adults suffers from depression. And that’s what has scientists puzzled. If depression is a detrimental1 condition, why is it so rampant2 in the population?
Some scientists think they may have the answer. Depression may have an evolutionary3 benefit. It may improve one’s chances of fighting off infection.
Scientists have known that depressed4 people display an immunoactive condition known as inflammation, even when they are not infected. For several years they have been finding that genes5 linked to depression also affect the function of the immune system. Stress, which can lead to depression, also modifies the immune system. These findings suggested that depression was somehow linked to the body’s ability to fight disease.
Some scientists now propose that depression might have had an evolutionary advantage in the days before modern medicine and antibiotics6. Infection was a major cause of death in early human history. Surviving those infections determined7 which genes were passed to the next generation.
They suspect that depression helped people, especially children, survive infection. Fatigue8 leads to inactivity and less social contact which helps keep infection from spreading. Shunning9 food helps avoid food sharing which can also spread infection. Sleeplessness10, which is associated with both depression and immune system activation11, may have been a mechanism12 to keep a person alert to fight off predators13 after injury.
If scientists are correct about this link, it could lead to new treatments for depression. They are interested in drugs that treat conditions where the immune system attacks the person’s own body, known as auto14 immune diseases. It is possible that medications known to treat auto immune disease may be successful in treating depression also.
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1 detrimental | |
adj.损害的,造成伤害的 | |
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2 rampant | |
adj.(植物)蔓生的;狂暴的,无约束的 | |
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3 evolutionary | |
adj.进化的;演化的,演变的;[生]进化论的 | |
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4 depressed | |
adj.沮丧的,抑郁的,不景气的,萧条的 | |
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5 genes | |
n.基因( gene的名词复数 ) | |
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6 antibiotics | |
n.(用作复数)抗生素;(用作单数)抗生物质的研究;抗生素,抗菌素( antibiotic的名词复数 ) | |
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7 determined | |
adj.坚定的;有决心的 | |
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8 fatigue | |
n.疲劳,劳累 | |
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9 shunning | |
v.避开,回避,避免( shun的现在分词 ) | |
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10 sleeplessness | |
n.失眠,警觉 | |
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11 activation | |
n. 激活,催化作用 | |
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12 mechanism | |
n.机械装置;机构,结构 | |
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13 predators | |
n.食肉动物( predator的名词复数 );奴役他人者(尤指在财务或性关系方面) | |
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14 auto | |
n.(=automobile)(口语)汽车 | |
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