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Five-hundred years ago, a 15-year-old Incan girl was sacrificed, along with two other children. Her mummy has now revealed that she had an active lung infection at her death. Because a technique called shotgun proteomics has been used to determine whether someone was actually suffering from a disease rather than just carrying it. The report appears in the journal PLoS ONE. [Angelique Corthals et al., Detecting the Immune System Response of a 500-Year-Old Inca Mummy]
Previous research into ancient diseases has used DNA1 analysis to determine the presence of pathogens. But with DNA, there's no way to tell latent infections from the full-blown, misery-inducing ones.
Researchers analyzed2 protein samples from the mummies of two of the slain3 children. The girl's proteins indicated an immune response to bacteria, perhaps a pathogen related to tuberculosis4. Other evidence, such as mucus under her nose and lung abnormalities, strengthened the diagnosis5. The seven-year-old boy, on the other hand, showed no signs of infection.
This is the first time the technique has been used. It’s a small sample, but further development of shotgun proteomics has the potential to improve our understanding of ancient disease, as well as assisting in tomorrow’s forensic6 investigations7.
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1 DNA | |
(缩)deoxyribonucleic acid 脱氧核糖核酸 | |
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2 analyzed | |
v.分析( analyze的过去式和过去分词 );分解;解释;对…进行心理分析 | |
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3 slain | |
杀死,宰杀,杀戮( slay的过去分词 ); (slay的过去分词) | |
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4 tuberculosis | |
n.结核病,肺结核 | |
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5 diagnosis | |
n.诊断,诊断结果,调查分析,判断 | |
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6 forensic | |
adj.法庭的,雄辩的 | |
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7 investigations | |
(正式的)调查( investigation的名词复数 ); 侦查; 科学研究; 学术研究 | |
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