纪录片《长生不老》 09限制卡路里不再有效（在线收听）

It had already been established that like mice,

这种联系已经开始在老鼠身上建立了

normal yeast lives longer on a calorie restricted diet.

正常酵母在控制卡路里后活得更长了

So with this in mind,

所以以此为基础

David removed the gene that triggered longevity

大卫去掉了长寿基因

and put this genetically modified yeast

再对此转基因酵母

on a calorie restricted diet to see if it still worked.

进行卡路里摄入限制 看这是否还有效

What the team discovered was that when this gene wasn't there

研究组发现当这个基因不再

any more in the yeast cells,

出现在酵母细胞内时

they didn't respond to the diet calorie restriction.

它们便对卡路里摄入限制没反应了

They didn't live longer so we knew that this gene,

细胞很快死去 因此我们得知这个基因

maybe others, were really important for this diet to work.

或者其他基因 对这种节食真的很重要

What was a really amazing discovery

有个惊人的发现

was to realise that this diet and these genes were part

就是这种节食和这些基因是同一系统的

of the same system, and that was a real breakthrough.

那才是真正的内幕

David felt he'd cracked it.

大卫觉得他有了突破

He'd shown that without the particular gene he'd identified,

他已证实没有他发现的那个特殊基因

calorie restriction would never work,

不管你吃得有多么的少

no matter how little you ate.

卡路里摄入限制就不再会有效

But what if he could find a

但他若能找到一种

drug that would activate this longevity gene

激活这个长寿基因的药

and mimic the effect of the diet.

那就会有这种节食的效果了