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(单词翻译:双击或拖选)
US Officials Worry Condition Disabling Children May Be Spreading
One morning last autumn, four-year-old Joey Wilcox did not feel right when he woke up. The boy had lost feeling on the left side of his face.
It was the first sign of a much more serious condition.
Three days later, Joey was in a hospital, unable to move his arms or legs or sit up. Tests failed to identify a cause. Doctors feared he might lose the ability to breathe.
“It’s devastating1,” his father, Jeremy Wilcox of Virginia, told the Associated Press. “Your healthy child can catch a cold — and then become paralyzed.”
Joey survived, but still suffers some of the effects. He was one of 228 confirmed victims of acute flaccid myelitis, known as AFM, in the United States last year.
AFM is a rare, mysterious and sometimes deadly paralyzing disorder2. The number of cases seems to rise and then fall every other year. The condition is beginning to worry public health officials because it is striking more and more children.
Anthony Fauci is head of the U.S. government’s National Institute of Allergy3 and Infectious Diseases. He said AFM appears similar to polio, another paralyzing disease. Polio affected4 only small numbers of people for centuries before it infected larger populations in the 19th and 20th centuries.
Fauci prepared a report about AFM that appeared earlier this month in the medical publication mBio.
Fauci said it is unlikely the disease will become as bad as polio, which struck tens of thousands of U.S. children every year before a vaccine5 became available in the 1950s. Yet he warned: “Don’t assume that it’s going to stay at a couple of hundred cases every other year.”
AFM cases have been reported in other countries, including Canada, France, Britain and Norway. But the size and shape of the U.S. outbreaks seem very different. More than 550 Americans have been struck over the past 10 years. The oldest was 32 years old. More than 90 percent of the patients were children, most around four, five or six years of age.
Many had a higher than normal body temperature and what seemed like a common viral infection. They seemed to recover, but then developed paralysis6. In some cases, it started in small ways — for example, a finger that suddenly would not move. Some went on to lose the ability to eat or breathe.
Many families say their children have regained7 at least some movement in affected body parts, but stories of complete recovery are unusual. Health officials cannot say how many recovered completely, partly or not at all, or how many have died. Yet the U.S. Centers for Disease Control and Prevention, or CDC, says deaths are rare.
Scientists suspect the disorder is being caused mainly by a virus that experts identified more than 55 years ago. They believe the virus may have changed to become more dangerous, but have yet to prove that.
Doctors have been using a number of treatments, such as antiviral medications and antibiotics8. But CDC officials say there is no clear evidence they work.
A growing number of experts agree that physical therapy does make a difference. A leading expert on the condition is Benjamin Greenberg of University of Texas Southwestern Medical Center in Dallas.
“These kids can continue to recover very slowly, year over year. ... It’s driven by how much therapy they do,” he noted9.
Joey Wilcox’s father said his son made huge improvements that way. Joey can run and use his arms. Still, the muscles in his right leg and shoulder are weak, and he still has left-side facial paralysis.
Katie Bustamante’s son Alex developed AFM in 2016. The California woman realized something was wrong when she asked her son, then five years old, why he was not eating. Alex said that his thumb had stopped working.
That morning was the start of 17 months of hospital stays, operations, therapy, and struggles with healthcare providers to find a way to restore his breathing. It ended one morning last May, when Alex died of problems related to the disorder.
Government officials need to step up, Bustamante said.
“I want them to research it and find the cause, and I want them to find a way to prevent it,” she said. “This is growing. This shouldn’t be happening.”
More and more experts feel strongly that the main cause is an enterovirus called EV-D68. Enteroviruses are a large family of viruses, some of which, such as polio, can damage the central nervous system. Many others cause mild problems or none at all.
Researchers have found a link between cases of AFM and a rise in breathing disorders11 caused by EV-D68.
In the United States, doctors began reporting breathing conditions tied to EV-D68 in 1987. But that was usually no more than about 12 cases in any given year.
Then, in what may have been one of the first signs of an AFM outbreak, a 5-year-old boy in New Hampshire died in 2008. First, he developed sensitivity around his neck and a high body temperature, then weakened arms and deadened legs. The boy had EV-D68, and researchers linked his death to the virus.
The first real outbreak of AFM cases hit in 2014, when 120 were confirmed, with the largest numbers in California and Colorado.
Cases dropped to 22 in 2015, jumped to 149 in 2016, and fell again, to 35 in 2017. Last year, they reached 228, a number that may grow because many are still being investigated. Just four cases have been confirmed in 2019 so far.
CDC officials consider a health problem to be AFM based on exams and other evidence showing a special kind of damage to the spinal12 cord. Proof of an enterovirus infection is not required for a case to be counted, mainly because such evidence has been hard to come by. To date, CDC investigators13 have been able to find evidence of enteroviruses in the spinal fluid of only four of 558 confirmed cases.
Scientists are using more powerful spinal-fluid tests in hopes of better establishing the connection between AFM and EV-D68. That, in turn, could lead to more organized efforts on treatments and maybe even a vaccine.
I’m Susan Shand.
And I’m Pete Musto.
Words in This Story
devastating – adj. causing extreme emotional pain
cold – n. a common illness that affects the nose, throat, and eyes and that usually causes coughing and sneezing
paralyzed – adj. a person or animal that is unable to move or feel all or part of the body
assume – v. to think that something is true or probably true without knowing that it is true
outbreak(s) – n. a sudden start or increase of fighting or disease
physical therapy – n. the treatment of a disease or an injury of the muscles or joints14 with massage15, exercises and heat
sensitivity – n. the quality of being easily affected by something in a bad or unpleasant way
neck – n. the part of the body between the head and the upper chest
spinal cord – n. the large group of nerves which runs through the center of the spine and carries messages between the brain and the rest of the body
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devastating
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| adj.毁灭性的，令人震惊的，强有力的 | |
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disorder
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| n.紊乱，混乱；骚动，骚乱；疾病，失调 | |
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allergy
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| n.(因食物、药物等而引起的)过敏症 | |
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affected
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| adj.不自然的，假装的 | |
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vaccine
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| n.牛痘苗，疫苗；adj.牛痘的，疫苗的 | |
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paralysis
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| n.麻痹(症)；瘫痪(症) | |
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regained
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| 复得( regain的过去式和过去分词 )； 赢回； 重回； 复至某地 | |
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antibiotics
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| n.（用作复数）抗生素；（用作单数）抗生物质的研究；抗生素，抗菌素( antibiotic的名词复数 ) | |
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noted
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| adj.著名的，知名的 | |
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tragic
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| adj.悲剧的，悲剧性的，悲惨的 | |
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disorders
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| n.混乱( disorder的名词复数 )；凌乱；骚乱；（身心、机能）失调 | |
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spinal
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| adj.针的，尖刺的，尖刺状突起的；adj.脊骨的，脊髓的 | |
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investigators
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| n.调查者，审查者( investigator的名词复数 ) | |
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joints
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| 接头( joint的名词复数 )； 关节； 公共场所（尤指价格低廉的饮食和娱乐场所） （非正式）； 一块烤肉 （英式英语） | |
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massage
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| n.按摩，揉；vt.按摩，揉，美化，奉承，篡改数据 | |
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