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New Studies on Omicron: Variant1 Multiplies at Slower Rate in Lungs
The Reuters news agency recently examined a group of new studies on COVID-19. These studies, for the most part, have yet to be closely examined by outside experts. They include information that needs further study to support their findings.
Omicron grows faster in airways3, slower in lungs
Researchers said last week that differences in how well Omicron and other variants4 of the coronavirus multiply may help predict Omicron's effects.
Compared to the earlier Delta5 variant, Omicron multiplies itself 70 times more quickly in tissues that line airway2 passages. This may speed up person-to-person spread, the researchers said. But in lung tissues, Omicron multiplies 10 times more slowly than the original kind of the coronavirus. This difference might lead to less-severe illness.
An official report of these findings is under careful study by a group of experts before publication and has not been released by the research team. In a news release issued by Hong Kong University, study leader Dr. Michael Chan Chi-wai said, "It is important to note that the severity of disease in humans is not determined6 only by virus replication" but also by each person's immune response to the infection. Such a response sometimes turns into life-threatening inflammation.
Chan added, "By infecting many more people, a very infectious virus may cause more severe disease and death even though the virus itself may be less pathogenic."
Pathogenic is a term that describes something such as a type of bacteria or a virus that causes disease.
Chan explained further, "taken together with our recent studies showing that the Omicron variant can partially7 escape immunity8 from vaccines9 and past infection, the overall threat from Omicron variant is likely to be very significant."
Omicron holds cells more tightly, withstands some antibodies
Another group of researchers said a model of how the Omicron variant attaches to cells and antibodies gives information about its behavior and will help in designing treatments.
Using computer models of the spike10 protein on Omicron's surface, they examined changes occurring when the spike grabs onto a cell-surface protein called ACE2, the virus' way into the cell.
The research team also modeled the spike with different classes of antibodies trying to attack it. The antibodies attack from different places, "like a football team's defense11 might tackle a ball carrier," said Joseph Lubin of Rutgers University in New Jersey12.
The findings, posted last week on the website bioRxiv ahead of examination by outside experts, need to be checked, "particularly with real-world samples from people," Lubin said. He added "while our molecular13 structure predictions are by no means a final word on Omicron, (we hope) they enable a faster and more effective response from the global community."
Four in 10 infected people may unknowingly spread virus
A third study, put online last week in the publication JAMA Network Open, showed that infected people who show no symptoms might be helping14 to spread SARS-CoV-2, the virus that causes COVID-19. Such cases, known as asymptomatic cases, could make up to 40.5 percent of confirmed infections worldwide.
Researchers grouped data from 77 earlier studies involving a total of 19,884 individuals with confirmed SARS-CoV-2 infections. They found that among infected people in the general community, about 40 percent were asymptomatic, as were 54 percent of infected pregnant women, 53 percent of infected air or cruise travelers, 48 percent of infected nursing home residents or staff and 30 percent of infected healthcare workers or hospitalized patients.
The grouped percentage of asymptomatic infections was about 46 percent in North America, 44 percent in Europe and 28 percent in Asia.
Min Liu and other researchers at Peking University in China wrote "the high percentage of asymptomatic infections highlights" the possible spread risk of "asymptomatic infections in communities."
The researchers added that officials should check for asymptomatic infections, and those who are identified "should be under management similar to that for confirmed infections, including isolating15 and contact tracing."
Words in This Story
multiply – v. to increase greatly in number or amount : to become much more numerous
replication –- n. to repeat or copy (something) exactly
inflammation -- n. a response to cellular16 injury that serves as a mechanism17 to eliminate harmful agents and damaged tissue
significant -- adj. very important
model -- n. A system of data presented as a mathematical description of something
tackle -- v. to try to get the ball from (an opposing player who has it); American football or rugby : to force (the player with the ball) to fall to the ground
1 variant | |
adj.不同的,变异的;n.变体,异体 | |
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2 airway | |
n.空中航线,通风口 | |
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3 AIRWAYS | |
航空公司 | |
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4 variants | |
n.变体( variant的名词复数 );变种;变型;(词等的)变体 | |
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5 delta | |
n.(流的)角洲 | |
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6 determined | |
adj.坚定的;有决心的 | |
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7 partially | |
adv.部分地,从某些方面讲 | |
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8 immunity | |
n.优惠;免除;豁免,豁免权 | |
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9 vaccines | |
疫苗,痘苗( vaccine的名词复数 ) | |
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10 spike | |
n.长钉,钉鞋;v.以大钉钉牢,使...失效 | |
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11 defense | |
n.防御,保卫;[pl.]防务工事;辩护,答辩 | |
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12 jersey | |
n.运动衫 | |
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13 molecular | |
adj.分子的;克分子的 | |
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14 helping | |
n.食物的一份&adj.帮助人的,辅助的 | |
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15 isolating | |
adj.孤立的,绝缘的v.使隔离( isolate的现在分词 );将…剔出(以便看清和单独处理);使(某物质、细胞等)分离;使离析 | |
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16 cellular | |
adj.移动的;细胞的,由细胞组成的 | |
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17 mechanism | |
n.机械装置;机构,结构 | |
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