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Rare Pancreatic Cancer Caused Steve Jobs' Death
Apple co-founder Steve Jobs' death at the age of 56 followed a seven-year battle with a rare form of pancreatic cancer - the fourth leading cause of cancer-related deaths in the United States. The disease is hard to treat because it is difficult to diagnose. The pancreas is embedded1 deep in the abdomen2, and often, symptoms of cancer become evident at a very late, advanced stage of the disease.
In 2004, Jobs announced he had undergone surgery for pancreatic cancer -- a mild and rare form of the disease called an islet-cell neuroendocrine tumor3.
That form makes up about five percent of all of pancreatic cancers. It affects the cells that produce hormones4 that control blood sugar levels. The more deadly, and common, form appears in the exocrine cells of the pancreas that produce digestive enzymes5.
The pancreas is a 15-centimeter-long gland6 tucked behind the stomach and below the liver. Pancreatic cancer can be hard to diagnose, since the early stages have no visible symptoms.
“Neuroendocrine tumor, when its detected early, it is curable with surgery alone," explained Dr. Khaled el-Shami, a cancer specialist at George Washington University Medical Center, in Washington. "And when it is advanced, meaning that it has spread from the pancreas to the liver, typically, or other organs - [then] this is [an] incurable7 disease.”
In 2009, five years after his cancer surgery, Jobs received a liver transplant.
"About five months ago I had a liver transplant. So I now have the liver of a mid-20's person,” Jobs said.
Dr. el-Shami says a liver transplant is an aggressive way of dealing8 with cancer, but it's no “magic bullet".
“It’s a balance between removing a big chunk9 of cancer in the liver and the risk of having a weakened immune system, which can encourage not only the original cancer to come back but also the emergence10 of other cancers,” the doctor explained.
While he never treated Steve Jobs and does not know the details of his case, Dr. Matthew Walsh, chairman of General Surgery at Cleveland Clinic says Jobs' cancer was never likely to be cured.
“Having gone through all the treatment, most patients might think that they are cured of the cancer. When it comes back, there is still a great uncertainty11 [about] what the length of your life will be. It tends to be a disease that does come back - does spread - does take your strength away sort of have all the cancer-associated symptoms and people still die from this type of cancer.”
Few details of Steve Jobs' health have ever been made public, but experts speculate that his cancer may have been a case of late diagnosis12.
1 embedded | |
a.扎牢的 | |
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2 abdomen | |
n.腹,下腹(胸部到腿部的部分) | |
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3 tumor | |
n.(肿)瘤,肿块(英)tumour | |
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4 hormones | |
n. 荷尔蒙,激素 名词hormone的复数形式 | |
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5 enzymes | |
n. 酶,酵素 | |
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6 gland | |
n.腺体,(机)密封压盖,填料盖 | |
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7 incurable | |
adj.不能医治的,不能矫正的,无救的;n.不治的病人,无救的人 | |
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8 dealing | |
n.经商方法,待人态度 | |
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9 chunk | |
n.厚片,大块,相当大的部分(数量) | |
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10 emergence | |
n.浮现,显现,出现,(植物)突出体 | |
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11 uncertainty | |
n.易变,靠不住,不确知,不确定的事物 | |
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12 diagnosis | |
n.诊断,诊断结果,调查分析,判断 | |
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