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Stem Cell Therapy Effective Against HIV Virus in Mice
"The actual stem cells were injected in my arm, said Diana Souza.
Diana Souza says stem cell therapy helped restore full use of her severely1 fractured arm.
“It is a miracle. It does work. And I have a good arm to prove it," she said.
Stem cell therapy works by providing new cells to replace the diseased cells and tissues.
At the California Institute of Regenerative Cures, Joseph Anderson is working on stem cell therapy for HIV infection. So far, he has been working with mice - replacing their immune systems with stem cells engineered with a triple combination of HIV-resistant2 genes3.
"They were able to block HIV infection, maintain a normal immune system in the mice, even though the virus was still there," said Joseph Anderson. "The resistant immune cells were able to maintain a normal immune cell level and maintain a functional4 immune system.
Anderson says this could provide a possible cure for people who are infected with HIV and have a severely compromised immune system. He says the genetically6-engineered stem cells will help them maintain a normal immune system through genetic5 resistance just as in the case of the mice.
“If it moves forward in human clinical trials we would be able to maintain a normal human immune system in patients that have HIV infection," he said. "Hopefully they will be able to stop taking antiretroviral drugs that they normally take because the genetically resistant stem cells will be able to fight off the virus in the body of the patients.”
Scientists working on this project say that, ideally, this would be a one-time treatment of stem cells charged with HIV-resistant genes. They hope that would generate an entire HIV-resistant immune system - making it possible to take patients off the antiretroviral drugs.
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1
severely
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adv.严格地;严厉地;非常恶劣地 | |
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2
resistant
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adj.(to)抵抗的,有抵抗力的 | |
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3
genes
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n.基因( gene的名词复数 ) | |
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4
functional
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adj.为实用而设计的,具备功能的,起作用的 | |
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5
genetic
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adj.遗传的,遗传学的 | |
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genetically
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adv.遗传上 | |
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