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Nobel in Chemistry for Seeing Biomolecules in Action

诺贝尔化学奖微化分子结构

“The Royal Swedish Academy of Sciences has decided to award the 2017 Nobel Prize in Chemistry jointly to Jacques Dubochet, Joachim Frank and Richard Henderson…for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution."

瑞典皇家科学院决定将2017年诺贝尔化学奖联合授予雅克·杜波切特、阿希姆·弗兰克和理查德·亨德森，以表彰其发明了冷冻电子显微镜，从而在高倍镜下观察到生物分子的结构性分离。

G?ran K. Hansson, secretary general of the Academy, at 5:53 this morning Eastern time.

瑞典皇家科学院常任秘书 G?ran K. Hansson于东部时间5：53发表了上述讲话。

Dubochet is honorary professor at the University of Lausanne in Switzerland. Frank is at Columbia University in New York. Henderson is at the Laboratory of Molecular Biology in Cambridge.

杜波切特是瑞士洛桑大学的荣誉教授。弗兰克任教于美国哥伦比亚大学。亨德森在剑桥大学分子生物实验室工作。

“The technique has transformed electron microscopy from a technique that could be used to just see the shapes, the outer shapes, of molecules into one that is now used to see the details, the atoms inside the molecules.

他们研发的技术将电子显微镜的技术从之前的只能看到分子的形状、外形转换为可以看到分子的具体细节以及分子内部的原子。

Peter Brzezinski is a professor of biochemistry at Stockholm University and a member of the Nobel Committee for Chemistry.

Peter Brzezinski是斯德哥尔摩大学的生物化学教授，同时也是诺贝尔化学委员会的成员。

“And the latest technical developments occurred very recently. So it’s recent developments that you can actually see the details of these molecules. The technique is also relatively rapid, so once one has samples that can be studied the structure can be determined relatively rapidly.

“这项新的技术刚刚研发出来，利用这项新的技术可以真切地看到这些分子的细节。但是这项技术见效很快，只要有可以用于研究分子结构的样本，人们就可以迅速判定分子结构。”

And this was exemplified last year when the structure of the Zika virus was determined in just a few months. And the structure shows the atomic details of the surface, which of course is important when developing drugs against the virus.”

去年寨卡病毒的结构在短短几个月内就被确定了，这就是一个很好的例子。得出的结构显示了表面的原子细节，当然，这对研发对抗病毒的药物具有重要意义。

For an in-depth listen about the 2017 Nobel Prize in Chemistry, look for the Scientific American Science Talk podcast later today.

更多关于2017年诺贝尔化学奖内容，请查询今日之后更新的科学美国人科学访谈播客节目。