新闻周刊:英国两人接种辉瑞新冠疫苗出现严重过敏反应(2)（在线收听）

A study of the data from the large-scale, Phase III clinical trial evaluating the Pfizer/BioNTech vaccine—published yesterday—showed that around 0.6 percent of people who received the shot had some form of allergic reaction during the testing, compared to about 0.5 percent in the group that were given a placebo.

昨天公布的一项对辉瑞/BioNTech疫苗进行评估的大规模III期临床试验的数据显示，在接受注射的人群中，约有0.6%的人在测试过程中出现了某种形式的过敏反应，而在服用无效对照剂的人群中，这一比例约为0.5%。

"So there was a genuine excess of allergic reaction but this was small and the true rate is not known, and there is a lot of uncertainty around that estimate," Evans said. "The only thing that is contraindicated with this vaccine—meaning you mustn't have it—is hypersensitivity to the vaccine or any of the excipients (other things in the vaccine,) but some people won't know if they have hypersensitivity to some constituents of the vaccine."

埃文斯说：“所以过敏反应确实过多，但概率很小，真实的过敏率还不得而知，这一评估还有很多不确定性。这种疫苗唯一禁用于对疫苗或任何辅药（疫苗中的其他物质）过敏的人，但有些人不知道他们是否对疫苗的某些成分过敏。”

The MHRA will now conduct an investigation to fully understand the allergic reactions experienced by the two NHS workers and their causes.

MHRA现在将进行一项调查，以充分了解两名NHS工作人员的过敏反应及其原因。

Individuals like the two NHS workers who need to carry EpiPens are at an increased risk of an allergic reaction from vaccines compared to the general population without a history of severe allergy, Dr. Penny Ward, a professor of pharmaceutical medicine at King's College London, said in a statement.

伦敦国王学院药学教授彭妮·沃德博士在一份声明中说，像这两名需要携带EpiPens的NHS工作人员这样的人，与没有严重过敏史的普通人群相比，因疫苗而产生过敏反应的风险更高。

"Previous epidemiological studies of anaphylaxis suggests that an anaphylactic reaction might be observed within a community in up to 30 out of 100,000 people followed over a year, by chance alone," she said.

她说：“以前关于过敏反应的流行病学研究表明，据观察，在一个社区内，10万人中有30人可能在一年多的时间里发生过敏反应，仅仅是偶然的。”。

"As these two events occurred in people with a history of severe allergy, it is sensible of the MHRA to draw attention to these reports and to suggest that individuals with a history of severe allergy not receive the vaccine at this time."

“由于这两个事件发生在有严重过敏史的人身上，MHRA应该引起对这些报告的注意，并建议有严重过敏史的人此时不接种疫苗。”