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(单词翻译:双击或拖选)
Doctors Operate on the Brain to Treat Drug Addiction1
Patient Number One is a thin man with all the hair removed from his head.
Years of drug use cost him his wife, his money and his self-respect.
Now, he meets with a surgeon who will operate on him in 72 hours. The doctor plans to cut two small holes in the man’s head and connect electrodes to his brain.
Doctors have long used the treatment, known as deep brain stimulation2, or DBS, for movement disorders4 like Parkinson’s disease. Now, they are performing the first clinical trial of DBS for methamphetamine addiction at the Ruijin Hospital in Shanghai, China.
Patient Number One was the first patient in the study.
The surgeon plans to implant5 a device that acts like a pacemaker for the brain. It electrically stimulates7 targeted areas.
Researchers in Europe have struggled to get patients for their DBS addiction studies. In the United States, complex social and scientific questions have made it hard to move forward with studies of the treatment.
Eight registered DBS clinical trials for drug addiction are taking place around the world. Six of those are in China. That information comes from the U.S. National Institutes of Health.
Patient Number One, whose last name is Yan, said doctors told him the surgery was not dangerous. “But I still get nervous,” he said. “It’s my first time to go on the operating table.”
Treating Addiction in China
Before brain implants8, there was brain lesioning. In China, families of heroin9 users paid doctors thousands of dollars to destroy small masses of brain tissue. Many patients had side effects, including emotional disorders and lost memories.
In 2004, China’s Ministry10 of Health ordered a stop to the use of brain lesioning.
DBS builds on that history. But unlike lesioning, which kills brain cells, DBS devices offer a treatment that is, at least in theory, reversible.
In China, DBS devices can cost less than $25,000. Many patients pay with money they have saved up.
Li Dianyou is Yan’s surgeon. “You can rest assured for the safety of this operation,” he told Yan. “It is no problem. When it comes to effectiveness, you are not the first one, nor the last one. You can take it easy because we have done this a lot.”
In fact, there are risks.
Yan could suffer brain damage. He could have had changes to his personality; he could have developed seizures11. He may have even gone right back to drugs.
DBS in the US
Critics believe the surgery should not be permitted. They argue that these experiments fail to deal directly with the issues that drive addiction.
Scientists do not fully12 understand how DBS works. They still debate where they should place electrodes to treat addiction.
Two U.S. clinical trials on DBS for depression failed around five years ago. At least two U.S. laboratories dropped clinical trials of DBS for treating alcoholism over concerns about study design. The partial results did not seem to justify13 the risks, researchers told the Associated Press.
The U.S. Centers for Disease Control and Prevention reports that over 500,000 Americans died of drug overdoses between 2008 and 2017. That is more than the total number of U.S. soldiers who died in World War II and Vietnam combined.
In February, the Food and Drug Administration approved a small trial of DBS for opioid use disorder3.
The FDA did not comment on the action.
“People are dying,” said Ali Rezai, the leader of the study at West Virginia University’s Rockefeller Neuroscience Institute on Drug Abuse. “Their lives are devastated14. It’s a brain issue. We need to explore all options.”
Nader Pouratian is a neurosurgeon at the University of California, Los Angeles. He is investigating the use of DBS for chronic15 pain. Pouratian said it is an “appropriate time” to research DBS for drug addiction, but only “if we can move forward in ethical16, well-informed, well-designed studies.”
What is this machine doing inside my head?
Yan, Patient Number One, had his surgery about six months ago. He was awake when the doctor used a drill to cut through his skull17. The noise made him shake.
Later the same day, he was given drugs so he could sleep through a second operation. Doctors implanted a battery pack in his chest to power the electrodes in his skull.
Hours after, Yan still had not woken up from the anesthesia. His father began crying. Doctors wondered if his drug use had changed how his body reacted to anesthesia.
Finally, 10 hours later, Yan opened his eyes.
Two days after the surgery, doctors turned on his DBS device.
When the device turned on, he felt energized18. He stayed awake that night; he said he spent the whole night thinking about drugs.
The next day, Doctor Li used a tablet computer to adjust the machine connected to Yan’s head.
?The doctor asked how Yan felt. “Agitated,” Yan said.
Li made a few changes. “Any feelings now?” he asked.
“Pretty happy now,” Yan said.
Yan notes that he felt the changes the machine made. “It controls your happiness, anger, grief and joy,” he said.
Six months later, Yan said he is still off drugs. His skin has improved and he has gained some weight.
Sometimes, in his new life, Yan touches the hard cable wiring in his neck. It leads from the battery pack to the electrodes in his brain. And he wonders: What is the machine doing inside my head?
I'm John Russell.
And I’m Alice Bryant.
Words in This Story
electrode – n. a point through which electricity flows into or out of a battery or other device
addiction – n. the condition of growing dependent on something
pacemaker – n. a machine for activating19 or controlling the heartbeat
stimulate6 – v. to produce activity or greater activity
alcoholism – n. a medical condition in which someone drinks too much alcohol and becomes unable to live a normal and healthy life
opioid – n. opioids are a class of drugs that include opium20, heroin, and synthetic21 drugs such as fentanyl
ethical – adj. involving questions of right and wrong behavior
drill – n. a tool used for making holes in hard substances
battery – n. a container with one or more cells in which chemical energy is made into electricity and used to make power
adjust – v. to change
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1
addiction
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| n.上瘾入迷，嗜好 | |
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stimulation
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| n.刺激，激励，鼓舞 | |
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disorder
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| n.紊乱，混乱；骚动，骚乱；疾病，失调 | |
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disorders
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| n.混乱( disorder的名词复数 )；凌乱；骚乱；（身心、机能）失调 | |
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implant
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| vt.注入，植入，灌输 | |
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stimulate
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| vt.刺激，使兴奋；激励，使…振奋 | |
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stimulates
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| v.刺激( stimulate的第三人称单数 )；激励；使兴奋；起兴奋作用，起刺激作用，起促进作用 | |
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implants
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| n.（植入身体中的）移植物( implant的名词复数 ) | |
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heroin
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| n.海洛因 | |
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ministry
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| n.(政府的)部；牧师 | |
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seizures
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| n.起获( seizure的名词复数 )；没收；充公；起获的赃物 | |
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fully
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| adv.完全地，全部地，彻底地；充分地 | |
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justify
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| vt.证明…正当(或有理)，为…辩护 | |
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devastated
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| v.彻底破坏( devastate的过去式和过去分词)；摧毁；毁灭；在感情上（精神上、财务上等）压垮adj.毁坏的；极为震惊的 | |
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15
chronic
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| adj.(疾病)长期未愈的，慢性的；极坏的 | |
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ethical
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| adj.伦理的，道德的，合乎道德的 | |
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skull
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| n.头骨；颅骨 | |
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energized
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| v.给予…精力，能量( energize的过去式和过去分词 )；使通电 | |
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activating
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| 活动的，活性的 | |
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opium
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| n.鸦片；adj.鸦片的 | |
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synthetic
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| adj.合成的，人工的；综合的；n.人工制品 | |
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