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(单词翻译:双击或拖选)
Wireless1 Microchip Delivers Bone Drug
Researchers have tested an implantable device that releases daily dosages of osteoporosis medicine.
The device may one day be a cost-effective alternative to daily injections, and could help manage other diseases as well.
Osteoporosis is a common condition of older people, especially women, in which bones become weak and brittle2, and can break easily.
There are medicines to treat osteoporosis. One kind, known as parathyroid hormone3, requires daily injections for two years.
But having to give yourself a shot every day, plus the lack of tangible4 improvement in the patient's condition, results in what researchers call poor compliance5.
"And as a result, only 25 percent of the patients will go through the entire 24 months of treatment," says Robert Farra, president of MicroCHIPS, a medical device maker6 that developed the implantable drug delivery system.
It's only a few centimeters long, and includes up to 365 tiny compartments8, each with a single dose of medicine. At the beginning of treatment, the device is inserted under the patient's skin.
"For osteoporosis, the physician will program the device, and the device has the ability to release a dose at a given time, every single day. For other diseases, where the physician may want to alter the dosing schedule, they will have the ability to wirelessly9 reprogram that dosing schedule," Farra says.
The injectable form of the parathyroid hormone is a liquid that has to be refrigerated, but for the implantable device, the researchers developed a powered version that remains10 effective when sealed in its tiny compartment7 for as long as a year.
The device itself can be implanted in a doctor's office with local anesthetic11.
Farra and his colleagues say safety tests of a small, 20-dose prototype unit were successful, and they are now designing a 365-dose version.
"We anticipate two years to complete the design, and then we may be required to do two additional trials, taking us out to a total of four years before the device is available on the commercial scale."
The price of the device is speculative12, but Farra says the cost should be similar to the current regimen of daily injections.
1 wireless | |
adj.无线的;n.无线电 | |
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2 brittle | |
adj.易碎的;脆弱的;冷淡的;(声音)尖利的 | |
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3 hormone | |
n.荷尔蒙,激素,内分泌 | |
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4 tangible | |
adj.有形的,可触摸的,确凿的,实际的 | |
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5 compliance | |
n.顺从;服从;附和;屈从 | |
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6 maker | |
n.制造者,制造商 | |
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7 compartment | |
n.卧车包房,隔间;分隔的空间 | |
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8 compartments | |
n.间隔( compartment的名词复数 );(列车车厢的)隔间;(家具或设备等的)分隔间;隔层 | |
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9 wirelessly | |
不用电线的,用无线电波传送的 | |
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10 remains | |
n.剩余物,残留物;遗体,遗迹 | |
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11 anesthetic | |
n.麻醉剂,麻药;adj.麻醉的,失去知觉的 | |
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12 speculative | |
adj.思索性的,暝想性的,推理的 | |
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