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(单词翻译:双击或拖选)
Juice Infused with Microscopic1 Particles Offers 'Unparalleled' View of Gut2
A new imaging technique involving a specially-prepared liquid that patients drink could help doctors better diagnose and eventually treat illnesses in the gut.
The small intestine3 is not small. And it’s not easy to examine. Sandwiched between the stomach and the large intestine, in an average adult it is 7 meters long and 2.5 centimeters thick. Getting a picture of it with X-rays, magnetic resonance4 imaging or ultrasound is limited because of safety issues, accessibility or low resolution.
University at Buffalo5 researchers wanted to get around those problems.
“We thought it would be interesting if we could make some type of thing that you could drink, and it would pass through your intestine without getting absorbed into your body so it would be safe," said Jonathan Lovell, assistant professor of biomedical engineering.
The scientists created a drink called nanojuice. It is infused with microscopic nanoparticles which contain molecules6 of a dye that absorb light from the infrared7 spectrum8.
“That’s the area of light that passes through your body the best," Lovell said. "If you have ever held up a flashlight to your hand or your ear, you can see the red light shining through. That type color of light can get through the body the best. So we made the nanojuice to absorb that color of light.”
The researchers gave the nanojuice to laboratory mice, then scanned their abdomens9 with a harmless laser light, in an imaging process called photoacoustic tomography. What they saw was an unparalleled view of the organ.
“You can actually see the intestine motor patterns," Lovell said. "You can pick out how the intestine is working in real time without any kind of invasive procedures.”
The nanojuice passed safely through the gut without being absorbed or degraded. Lovell hopes to move to human clinical trials in the near future, which he says could ultimately lead to a better understanding of how the intestine works.
“To try to help people shed light on not only disease diagnosis10, but also treatment and see if the treatments that are being prescribed by the doctors are affecting the disease that people have in the gastrointestinal track,” Lovell said.
Lovell's team has made the nanojuice in four different colors, which he says in theory could be used at the same time to look at the diseased tissues as the nanojuices move through them.
1 microscopic | |
adj.微小的,细微的,极小的,显微的 | |
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2 gut | |
n.[pl.]胆量;内脏;adj.本能的;vt.取出内脏 | |
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3 intestine | |
adj.内部的;国内的;n.肠 | |
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4 resonance | |
n.洪亮;共鸣;共振 | |
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5 buffalo | |
n.(北美)野牛;(亚洲)水牛 | |
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6 molecules | |
分子( molecule的名词复数 ) | |
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7 infrared | |
adj./n.红外线(的) | |
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8 spectrum | |
n.谱,光谱,频谱;范围,幅度,系列 | |
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9 abdomens | |
n.腹(部)( abdomen的名词复数 ) | |
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10 diagnosis | |
n.诊断,诊断结果,调查分析,判断 | |
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