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This is Scientific American's 60-Second Science. I'm Cynthia Graber. This will just take a minute.
Scientists can now include online gaming in their problem-solving arsenal1. Because game players seem to have provided an answer to a scientific question that's vexed2 researchers for a decade.
Scientists wanted to know the structure of a protein-cutting enzyme3 produced by a retrovirus similar to HIV. They haven't been able to solve the protein structure using standard computational methods.
Now, the game—researchers developed Foldit in 2008. Teams of players fold molecules4 and rotate amino acids to create 3-D protein structures. Gamers get points for structure stability.
So researchers asked gamers to try to solve this particular protein. Within three weeks, the gamers found a good solution. The scientists then refined it and were able to completely determine the protein's structure. Having the structure could inform the use of drugs to block the enzyme, and provide another tool against retroviruses, including HIV.
The researchers say that people have better spatial5 reasoning skills than computers—and that having both humans and machines attack the problem might overcome various structural6 challenges. The results appear in the journal Nature Structural and Molecular7 Biology.Co-authored by researchers—and a number of gamers.
Thanks for the minute. For Scientific American's 60-Second Science, I'm Cynthia Graber.
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1 arsenal | |
n.兵工厂,军械库 | |
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2 vexed | |
adj.争论不休的;(指问题等)棘手的;争论不休的问题;烦恼的v.使烦恼( vex的过去式和过去分词 );使苦恼;使生气;详细讨论 | |
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3 enzyme | |
n.酵素,酶 | |
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4 molecules | |
分子( molecule的名词复数 ) | |
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5 spatial | |
adj.空间的,占据空间的 | |
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6 structural | |
adj.构造的,组织的,建筑(用)的 | |
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7 molecular | |
adj.分子的;克分子的 | |
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