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Ebola Vaccine1 Enters Final Trial Phase 埃博拉病毒疫苗进入最后审判阶段
An Ebola vaccine candidate enters the final phase of its trial Saturday (3/7) in Guinea. If successful, a vaccine could be ready for use in five or six months.
The VSV-EBOV vaccine was developed by Canada’s Public Health Agency. World Health Organization vaccine expert Dr. Marie-Pierre Préziosi said Phase III will be conducted in the Basse Guinée region. It’s had the highest number of Ebola cases in the country
“Phase III trial aims to test for safety and efficacy or effectiveness of a candidate vaccine. This is a final trial prior to licensure of a vaccine. The vaccination2 phase in itself is anticipated to last about 60 days. And then there will be a follow-up period of about 84 days. That is about three months. So altogether it should be around six months duration,” she said.
The vaccine is based on a genetically3 engineered virus that’s been given some proteins of the Ebola virus.
“This is a very common technique to make good vaccines,” she said.
The strategy being used in the Phase III trial is known as “ring vaccination.” It’s a technique that was used to eradicate4 smallpox5 in the 1970s. Researchers identify a newly diagnosed Ebola patient, who is called the “index case.” Then they trace all of his or her contacts and vaccinate6 them, if they give their consent. The goal is to create a buffer7 zone that prevents the spread of the disease.
Dr. Préziosi said it’s important to have an Ebola vaccine even though the number of new cases is on the decline.
“Although we see that cases are declining and the outbreak seems to be waning8, unfortunately, as we speak there are still cases in various locations in Guinea. So, this really tells us that the epidemic9 is not over. We need to continue because this environment is quite unpredictable and the epidemic might flare-up again. And also if we are able to have an effective vaccine it would be really an invaluable10 tool to fight this outbreak and any other outbreak that would come in the future.”
She said a vaccine could be used in several ways in the next Ebola outbreak. For example, it could be given only to frontline workers – those in direct contact with patients – or given to large portions of a country’s population.
“We are all holding our breath because we are living a very important moment for this outbreak and for any future outbreak,” she said.
It’s not clear what the cost of an Ebola vaccine dose will be.
1 vaccine | |
n.牛痘苗,疫苗;adj.牛痘的,疫苗的 | |
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2 vaccination | |
n.接种疫苗,种痘 | |
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3 genetically | |
adv.遗传上 | |
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4 eradicate | |
v.根除,消灭,杜绝 | |
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5 smallpox | |
n.天花 | |
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6 vaccinate | |
vt.给…接种疫苗;种牛痘 | |
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7 buffer | |
n.起缓冲作用的人(或物),缓冲器;vt.缓冲 | |
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8 waning | |
adj.(月亮)渐亏的,逐渐减弱或变小的n.月亏v.衰落( wane的现在分词 );(月)亏;变小;变暗淡 | |
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9 epidemic | |
n.流行病;盛行;adj.流行性的,流传极广的 | |
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10 invaluable | |
adj.无价的,非常宝贵的,极为贵重的 | |
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